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Project:	A3

Title:          Serial protein crystallography using non-monochromatic x-ray beam and electrons

DESY group:     FS-CFEL-1 (Coherent Imaging Group)

Type:           Remote project

Duration:       19th july - 10th sep 2021

Description: 
Our group (group leader H.N.Chapman) is developing methods of using non-monochromatic (“pink”) x-ray beam and electron beam to study protein crystals. Mostly we are doing it for Serial Crystallography (SX) – the method when many protein crystals are measured in random orientations to get the full 3D structure of the protein. Usage of “pink” beam allows to study fast dynamics (down to 100ps) while electron diffraction can be performed in the lab, without the need to access synchrotrons. Our group is developing algorithms for processing both “pink” and electron diffraction data measured during SX experiments.
We have already collected a lot of data at the most advances sources in the world (for pink beam at APS and ESRF and for electrons at SLAC and DESY) and in the recent future we plan to perform more experiments. Each experiment produces up to 100Tb of diffraction frames, so we have a lot of interesting data to process. And the result of such experiment is usually published in a high impact factor journal.
The summer student has a chance to participate in some experiments (most probably remotely) – depending on the schedule of the beamtimes during summer. Also the student is encouraged to contribute in the software development. If the student likes the activity, the scientific collaboration can be extended outside the time frame of the summer school and become more permanent.


Special Qualifications expected: 
Some knowledge in protein crystallography, python and using Linux will be useful.


Link to further information: 
https://cid.cfel.de/
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